Nitrogen has been used to inflate critical tire applications for years, primarily because it doesn't support moisture or combustion. These include racing tires, aircraft tires (commercial and military) and heavy-duty equipment tires (earthmovers and mining equipment).
The reason racing tires are inflated with nitrogen, rather than the normal air we pump into our tires, is due to the increased stability under hotter temperatures that the gas exhibits. It allows the tire pressure (50 PSI to remain constant throughout the race regardless of the temperature, which can reach 200 degrees Fahrenheit.
The U.S. Federal Aviation Administration issued Airworthiness Directive 87-08-09 requiring that only nitrogen, with a minimum purity of 95%, be used to inflate airplane tires on braked wheels.